Muhammad isa Khan
Title: Dosimetric comparison of radiation treatment plans on multi-targeted lung cancer: A phantom study using IMRT and VMAT
Biography
Biography: Muhammad isa Khan
Abstract
Purpose: To analyze the dosimetric difference between the intensity modulated radiotherapy (IMRT), partial/single/double-arc volumetric modulated arc therapy (PA/SA/DA-VMAT) techniques in treatment planning for treating more than one target of lung cancer at different isocenters. Materials and methods: IMRT and VMAT plans at different isocenters were created systematically using a Harold heterogeneous lung phantom. The Conformity index (CI), homogeneity index (HI), gradient index (GI), dose-volume histogram and mean and maximum dose of the PTV were calculated and analyzed. Furthermore, the dose-volume histogram and mean and maximum doses of the OARs such as right lung, contralateral lung and non GTV were determined from the plans. Results: The IMRT plans showed the superior target dose coverage, higher mean and maximum values than other VMAT techniques. PA-VMAT technique shows more lung sparing and DA-VMAT increases the V5/10/20 values of contralateral lung than other VMAT and IMRT techniques. Conclusions: The IMRT technique achieves highly conformal dose distribution to the target than other VMAT techniques. Comparing to the IMRT plans, the higher V5/10/20 and mean lung dose were observed in the contralateral lungs in the DA-VMAT. Keywords: Lung cancer, Intensity-modulated radiotherapy, Volumetric modulated arc therapy, Target dose distribution