Medical Physics

Biography

Biography: Natassa Pippa

Abstract

Fractal analysis can be an attractive and alternative tool for characterizing the morphology of nanoparticles [1-3]. From the experimental point of view, determined fractal dimension comprehensively illustrates the self-assembly and the morphological complexity of drug nanocarriers. In recent literature, it is well established that the regulatory considerations are of great importance aiming at providing proof, concerning not only the design and preparation protocol of drug delivery systems, but also the final formulation’s physicochemical and morphological characteristics, especially in the pharmaceutical nanotechnology’s area. Additionally, fractal dimension plays a key role in the elucidation of morphological characteristics, while size and/or size distribution of drug nanocarriers did not change by changing the colloidal parameters, like temperature and concentration. In coming years, the above approach could be a useful tool for the development of innovative drug nanocarriers for drug or gene delivery with complete knowledge of their structural and morphological characteristics [4-5]. In conclusion, on the ubiquitous presence of fractals and fractal concepts in Pharmaceutical Sciences, the “pharmaceutical fractalomics” a term which can be correlated with other –omics in pharmaceutics can be considered as an alternative path in the field of novel pharmaceutics. Ref.: [1] Pippa, N., Kaditi, E., Pispas S., Demetzos C., (2013) Soft Matter, 9, 4073-482. [2] Pippa, N., Kaditi, E., Pispas S., Demetzos C., (2013) J. Nanopart. Res., 15,1685.[3] Pippa, N., Merkouraki, M., Pispas S., Demetzos C., (2013) Int. J. Pharm. 450(1-2),1-10. [4] Demetzos, C., Pippa, N., (2014). Int. J. Pharm. 473(1-2):213-8. [5] Pippa N., Dokoumetzidis, A., Demetzos, C., Macheras, P. (2014). Int. J. Pharm. 456(1-2):340-52.