Day 1 :
Keynote Forum
Gad Shani
Ben Gurion University, Israel
Keynote: The Use of Beta-Gamma Source for HDR Brachytherapy
Biography:
Gad Shani has completed his PhD at Cornell University in 1970. He has been on the faculty of Ben Gurion University in Israel since then. He served as the head of the department of Nuclear Engineering and later as the head of the department of Biomedical Engineering. He has published more than 90 papers in referred journals and served on many university, national and international bodies.
Abstract:
Brachytherapy is generally done with photon emitting isotopes (I-125 for LDR and Ir-192 for HDR). Beta Emitters are rarely used. We have found that beta-gamma emitters have some important benefits as sources for brachytherapy. The main benefit is saving millions of Dollars in building expensive treatment rooms with remote control systems. The second benefit is that the medical personnel can stand by the patient while treatment is done, without radiation hazard. High dose to the tumor can be obtained, evenly distributed with very little radiation damage to surrounding organs\\\\\\\\r\\\\\\\\nExperimental work where Tm-170 HDR source (3 Ci) was used, to cure cancer on rats was carried out. It demonstrates the potential of using Tm-170 for medical brachytherapy. Tm-170 emits gamma ray of energy 84 keV and a number of x-ray in the range 50-60 keV. It also emits a large number of beta rays of E-max= 968 (80%) and E-max=883 keV (20%). An HDR source was made by sealing a thulium wire, 0.6 mm diameter 4 mm long, in titanium tubes and activated by neutrons. Experiments were done with Lewis rats, carrying tumor developed from implantation of CNS1 Rat Brain Tumor Astrocytoma cells, under the thigh skin.\\\\\\\\r\\\\\\\\n75% of the treated rats were completely cured, 16.7% had their tumor delayed and 8.3% were not cured. The total dose delivered to the different rats was 30-60 Sv photon dose and 2.5x10**3-5x10**3 Sv beta dose at 2 mm from the source. \\\\\\\\r\\\\\\\\n
Keynote Forum
Cecilia Arsene
University of Iasi, Romania
Keynote: Chemical composition of aerosols, a fragile barrier between healing and wounding
Biography:
Cecilia Arsene graduated in chemistry from the “Alexandru Ioan Cuza†University of Iasi, Romania. In 2001 she received a PhD degree (Doktors der Naturwissenchaften, Dr. rer. nat.) at the Bergischen Universität Gesamthochschule Wuppertal, Germany. Within 2005-2007 she performed postdoctoral research at the University of Crete, Greece. From February 2015 she is a professor in chemistry at the “Alexandru Ioan Cuza†University of Iasi, Romania. Her research interests include kinetics and mechanisms of different oxidation processes, investigations of various gas-to-particle conversion processes, aerosols chemical composition and chemistry. She has published more than 40 research papers in peer reviewed international journals.
Abstract:
Aerosols are air suspended mixture of solid and liquid particles varying especially in size and chemical composition. For anthropogenic source related aerosols, origin is a third factor controlling their distribution. Coarse particles (PM10) are mainly of natural origin while fine (PM2.5) and ultrafine (PM0.1) particles derive from anthropogenic sources and from photochemical induced processes. Aerosols play an important role in climate change. Nowadays the interest towards aerosols is increasing because they influence visibility, contribute to acid rain, and have high potential to affect human health. Fine and ultrafine particles, often of very complex chemical composition (i.e. sulphates, nitrates, acids, metals, carbon loaded particles), are the most susceptible to be breathed most deeply in the lungs. However, the mechanisms by which ultrafine particles penetrate through pulmonary tissue and enter capillaries are still unknown. There are reliable measurements clearly showing that World Health Organization (WHO) recommendations in terms of atmospheric aerosols levels are overwhelming for certain periods in some world’s area. In specific area most probably the high aerosol levels are probably linked to the high rate of various pulmonary diseases. However, in medical practical applications, the efficiency of aerosols and nanoparticles in prevention, care and cardio-respiratory function improvement is believed to depend on aerosols life time, abundance and shape, which should be very strictly controlled. There are reports showing that selected halides might influence the generation mechanism of saline aerosols. These findings might have potential implications in the optimization processes of particles generation by dynamic halochambers used in various medical applications.
Keynote Forum
Nicolas Pourel
Institut sainte- Catherine, France
Keynote: Patient information duties in Radiation Oncology
Biography:
Nicolas Pourel has completed his degree (MD) as a Radiation Oncologist in 1999 at Nancy Science University (Faculty of Medicine) and a Diplome d’Etudes Approfondies (DEA) in Epidemiology at Nancy School of Public Health in 2001. He is the head of radiation oncology department at Institut Sainte-Catherine, particularly involved in Risk management. He is also a member of the board of Societe Francaise de Radiotherapie Oncologique (SFRO) and the Association de Formation Continue en Oncologie Radiotherapique (AFCOR). He is a teacher for ESTRO school on Comprehensive Quality Management in Radiotherapy and also for the IAEA on the same topic.
Abstract:
Patient information duties are a basic task of Radiation Oncologists in their daily practice. This workshop will illustrate all the aspects of legal obligations taking the context of French Law as an example : the basic principles of the Law, who has to bring evidence of information and through which support in case of litigation, who is supposed to inform the patient, the principles of the individual interview between him/her and his/her physician, the documents that ought to be given to illustrate the practical aspects of treatment and its side effects, the value of written informed consent and when it is mandatory (clinical trial) are to be illustrated here. \r\nWe will try to focus particularly on how the first consultation of the patient (aka, ‘announcement consultation’) ought to be structured, knowing that, in most cases, most of the information is to be given orally but the key messages of that interview have to be simple, understandable and loyal, especially concerning the acute side effects and late sequellae of radiotherapy.\r\nA special emphasis will also be put on information documents that are to be given to the patient (basically, personalized treatment plan, disease specific and/or treatment-specific brochures, and, in some cases, a formal written consent form), especially in order to give a fair, comprehensive and clear information on the benefits and the risk of radiotherapy that has to be delivered.\r\n
Keynote Forum
Geoffrey Mitchell
Portugal and the Royal Berkshire NHS Foundation Trust, UK
Keynote: The opportunities for Direct Digital Manufacturing in Medicine
Biography:
Geoffrey Mitchell completed his PhD in Materials Physics working at Cambridge. He undertook postdoctoral studies at Hokkaido University and subsequently moved to the University of Reading UK where he eventually became Professor of Polymer Physics. He is currently Vice-Director of the Centre for Rapid and Sustainable Product Development, a leader in the development of Direct Digital Manufacturing especially in the application of such technology to medicine. He has published more than 300 papers in reputed journals and 4 books.
Abstract:
Direct Digital Manufacturing is a set of technologies which are set to revoluntinze manufacturing. Direct Digital Manufacturing is able to directly produce an object from a digital definition without the use of moulds or other specific tooling. As such it is particularly suited to objects or process which require mass customisation. This is clearly has huge potential in the field of medicine and healthcare for which personalisation is a critical requirement for many devices. Direct Digital Manufacturing involve additive manufacturing procedures which include 3d printing, stereolithography and selective laser melting. We review these technologies with regard to their potential for medical applications and we consider the changing landscape of direct digital manufacturing as it develops the capacity for functionally graded materials, functional materials and the move from design by form to design by function. We illustrate the possibilities using current projects from the broad based portfolio of work on direct digital manufacturing currently underway at CDRSP. A major use of direct digital manufacturing is the generation of scaffolds for tissue engineering. However, the scope for medical applications of direct digital manufacturing is much wider than that and we speculate on the future trends.
- Track-1: Latest imaging techniques
Track-2:Clinical physics and patient safety
Track-3:Biophysics & modellings
Session Introduction
Gad Shani
Ben Gurion University, Israel
Title: The Use of Beta-Gamma Source for HDR Brachytherapy
Biography:
Gad Shani has completed his PhD at Cornell University in 1970. He has been on the faculty of Ben Gurion University in Israel since then. He served as the head of the department of Nuclear Engineering and later as the head of the department of Biomedical Engineering. He has published more than 90 papers in referred journals and served on many university, national and international bodies.
Abstract:
Brachytherapy is generally done with photon emitting isotopes (I-125 for LDR and Ir-192 for HDR). Beta Emitters are rarely used. We have found that beta-gamma emitters have some important benefits as sources for brachytherapy. The main benefit is saving millions of Dollars in building expensive treatment rooms with remote control systems. The second benefit is that the medical personnel can stand by the patient while treatment is done, without radiation hazard. High dose to the tumor can be obtained, evenly distributed with very little radiation damage to surrounding organs Experimental work where Tm-170 HDR source (3 Ci) was used, to cure cancer on rats was carried out. It demonstrates the potential of using Tm-170 for medical brachytherapy. Tm-170 emits gamma ray of energy 84 keV and a number of x-ray in the range 50-60 keV. It also emits a large number of beta rays of E-max= 968 (80%) and E-max=883 keV (20%). An HDR source was made by sealing a thulium wire, 0.6 mm diameter 4 mm long, in titanium tubes and activated by neutrons. Experiments were done with Lewis rats, carrying tumor developed from implantation of CNS1 Rat Brain Tumor Astrocytoma cells, under the thigh skin. 75% of the treated rats were completely cured, 16.7% had their tumor delayed and 8.3% were not cured. The total dose delivered to the different rats was 30-60 Sv photon dose and 2.5x10**3-5x10**3 Sv beta dose at 2 mm from the source.
Cecilia Arsene
Alexandru Ioan Cuza†University of Iasi, Romania
Title: Chemical composition of aerosols, a fragile barrier between healing and wounding
Biography:
Cecilia Arsene graduated in chemistry from the “Alexandru Ioan Cuza†University of Iasi, Romania. In 2001 she received a PhD degree (Doktors der Naturwissenchaften, Dr. rer. nat.) at the Bergischen Universität Gesamthochschule Wuppertal, Germany. Within 2005-2007 she performed postdoctoral research at the University of Crete, Greece. From February 2015 she is a professor in chemistry at the “Alexandru Ioan Cuza†University of Iasi, Romania. Her research interests include kinetics and mechanisms of different oxidation processes, investigations of various gas-to-particle conversion processes, aerosols chemical composition and chemistry. She has published more than 40 research papers in peer reviewed international journals.
Abstract:
Aerosols are air suspended mixture of solid and liquid particles varying especially in size and chemical composition. For anthropogenic source related aerosols, origin is a third factor controlling their distribution. Coarse particles (PM10) are mainly of natural origin while fine (PM2.5) and ultrafine (PM0.1) particles derive from anthropogenic sources and from photochemical induced processes. Aerosols play an important role in climate change. Nowadays the interest towards aerosols is increasing because they influence visibility, contribute to acid rain, and have high potential to affect human health. Fine and ultrafine particles, often of very complex chemical composition (i.e. sulphates, nitrates, acids, metals, carbon loaded particles), are the most susceptible to be breathed most deeply in the lungs. However, the mechanisms by which ultrafine particles penetrate through pulmonary tissue and enter capillaries are still unknown. There are reliable measurements clearly showing that World Health Organization (WHO) recommendations in terms of atmospheric aerosols levels are overwhelming for certain periods in some world’s area. In specific area most probably the high aerosol levels are probably linked to the high rate of various pulmonary diseases. However, in medical practical applications, the efficiency of aerosols and nanoparticles in prevention, care and cardio-respiratory function improvement is believed to depend on aerosols life time, abundance and shape, which should be very strictly controlled. There are reports showing that selected halides might influence the generation mechanism of saline aerosols. These findings might have potential implications in the optimization processes of particles generation by dynamic halochambers used in various medical applications.
Nicolas Pourel
Institut Sainte-Catherine, France
Title: Patient information duties in Radiation Oncology
Biography:
Nicolas Pourel has completed his degree (MD) as a Radiation Oncologist in 1999 at Nancy Science University (Faculty of Medicine) and a Diplome d’Etudes Approfondies (DEA) in Epidemiology at Nancy School of Public Health in 2001. He is the head of radiation oncology department at Institut Sainte-Catherine, particularly involved in Risk management. He is also a member of the board of Societe Francaise de Radiotherapie Oncologique (SFRO) and the Association de Formation Continue en Oncologie Radiotherapique (AFCOR). He is a teacher for ESTRO school on Comprehensive Quality Management in Radiotherapy and also for the IAEA on the same topic.
Abstract:
Patient information duties are a basic task of Radiation Oncologists in their daily practice. This workshop will illustrate all the aspects of legal obligations taking the context of French Law as an example : the basic principles of the Law, who has to bring evidence of information and through which support in case of litigation, who is supposed to inform the patient, the principles of the individual interview between him/her and his/her physician, the documents that ought to be given to illustrate the practical aspects of treatment and its side effects, the value of written informed consent and when it is mandatory (clinical trial) are to be illustrated here. We will try to focus particularly on how the first consultation of the patient (aka, ‘announcement consultation’) ought to be structured, knowing that, in most cases, most of the information is to be given orally but the key messages of that interview have to be simple, understandable and loyal, especially concerning the acute side effects and late sequellae of radiotherapy. A special emphasis will also be put on information documents that are to be given to the patient (basically, personalized treatment plan, disease specific and/or treatment-specific brochures, and, in some cases, a formal written consent form), especially in order to give a fair, comprehensive and clear information on the benefits and the risk of radiotherapy that has to be delivered.
Geoffrey Mitchell
Portugal and the Royal Berkshire NHS Foundation Trust, UK
Title: The opportunities for Direct Digital Manufacturing in Medicine
Biography:
Geoffrey Mitchell completed his PhD in Materials Physics working at Cambridge. He undertook postdoctoral studies at Hokkaido University and subsequently moved to the University of Reading UK where he eventually became Professor of Polymer Physics. He is currently Vice-Director of the Centre for Rapid and Sustainable Product Development, a leader in the development of Direct Digital Manufacturing especially in the application of such technology to medicine. He has published more than 300 papers in reputed journals and 4 books.
Abstract:
Direct Digital Manufacturing is a set of technologies which are set to revoluntinze manufacturing. Direct Digital Manufacturing is able to directly produce an object from a digital definition without the use of moulds or other specific tooling. As such it is particularly suited to objects or process which require mass customisation. This is clearly has huge potential in the field of medicine and healthcare for which personalisation is a critical requirement for many devices. Direct Digital Manufacturing involve additive manufacturing procedures which include 3d printing, stereolithography and selective laser melting. We review these technologies with regard to their potential for medical applications and we consider the changing landscape of direct digital manufacturing as it develops the capacity for functionally graded materials, functional materials and the move from design by form to design by function. We illustrate the possibilities using current projects from the broad based portfolio of work on direct digital manufacturing currently underway at CDRSP. A major use of direct digital manufacturing is the generation of scaffolds for tissue engineering. However, the scope for medical applications of direct digital manufacturing is much wider than that and we speculate on the future trends.
Julianna C. Simon
University of Washington, USA
Title: Determination of porcine renal injury thresholds for therapeutic ultrasound
Biography:
Julianna Simon completed her PhD in 2013 from the University of Washington. She is currently working as a National Space Biomedical Research Institute First Award Postdoctoral Fellow at the University of Washington. She has co-authored 12 papers.
Abstract:
The global prevalence of kidney stones is rising, and nearly half of patients that undergo surgical intervention experience complications associated with residual stone fragments that are not passed. Ultrasonic propulsion is a new therapeutic technique to non-invasively clear stones, which, in a clinical simulation, proved effective at repositioning kidney stones in pigs. The goal of this study was to establish a range of intensities under which stones could be repositioned without injury. A 2-MHz annular array was placed on the surface of in vivo porcine kidneys and focused in the proximal parenchyma. Individual exposures of 10-minute duration were comprised of duty cycles from 0-100% and spatial peak pulse-averaged intensities up to 26 kW/cm2 (derated through 1 cm of kidney tissue). The kidneys were histologically evaluated for injury by up to three independent experts blinded to the exposure conditions. The injury threshold for 100-μs ultrasound bursts repeated with a 3.3% duty cycle was 16.6 kW/cm2 (derated). As the first generation prototype to reposition kidney stones utilized the same pulsing parameters with a maximum derated intensity of 2.4 kW/cm2, the technique was shown to be safe. The injury threshold for exposures at 100% duty cycle was 0.5 kW/cm2 (derated). This study showed that a range exists above diagnostic imaging levels and below tissue injury levels for which ultrasound therapies can be safely developed. [Work supported by the National Space Biomedical Research Institute through NASA NCC 9-58 and NIH grants DK043881 and DK092197].
Ekaterina Saukko
Turku University Hospital, Finland
Title: The establishment of local DRLs for ERCP – a practical tool for the optimization of patient radiation doses and for quality assurance management
Biography:
Ekaterina Saukko has completed her Master’s degree in 2014 at the University of Oulu in the Finland and applied for PhD program to the University of Oulu Graduate School in 2015. She is working as a research coordinator in The Medical Imaging Centre of Southwest Finland at Turku University Hospital, Finland. Her research interests include interventional radiology, radiography, fluoroscopy, ERCP, radiation protection, pediatric imaging and evidence-based radiography. She has published a scientific article on dosimetry in interventional radiology and participated in international conferences with oral presentation and posters.
Abstract:
Endoscopic retrograde cholangiopancreatography (ERCP) has the potential for high patient dose, which is why attention is required regarding radiation protection. The first step towards patient dose optimization is to establish the diagnostic reference levels (DRLs) for ERCP. The establishment of DRLs might be beneficial in view of the large variation of dose area product (DAP) reported during ERCP. If national DRLs are not available, it is recommended that local ones be established and compared with more current patient dose levels regularly. Consequently, there was an essential need to establish local DRLs for ERCP in our hospital. A total of 105 patient radiation doses in ERCP were recorded during a 4-month period in 2010. For each procedure, DAP, fluoroscopy time, cumulative skin dose and number of images were collected. Patient body characteristics, such as age, sex, height, weight and body mass index (BMI) were registered as well. DRLs were set at the point of 75th percentile for both DAP and fluoroscopy time. According to the results, the 75th percentiles of DAP was 2.40 Gy∙cm2 and fluoroscopy time 2.13 min, respectively. In 2015, the local DRLs for ERCP were reviewed by collecting the similar data of 20 procedures. The effect on the radiation dose level requires further studies. The collection of such patient exposure data will increase awareness of the level of exposure involved in ERCP and the settled local DRLs could serve as a baseline for further studies concerning patient dose optimization with regard to avoiding and minimizing unnecessary radiation risks.
Jukka Järvinen
Turku University Hospital, Finland
Title: KARPO – the study of radiation doses in cardiological interventional procedures
Biography:
Jukka Järvinen is a Lic. Phil. doing his PhD in medical physics in University of Turku. He works as medical physicist in Turku Heart Centre and The Medical Imaging Centre of Southwest Finland. His research interests lie in interventional radiology, radiation protection and evidence based radiography. He has authored one and co-authored several scientific papers and participated in international conferences by oral presentations and posters.
Abstract:
Long cardiological procedures pose radiation risk to both patients and performing staff. In literature, the radiation dose to the patient is presented mainly without taking into consideration difficulty level of the procedure. The purpose of KARPO is to examine dose levels involved in cardiological interventional procedures taking into account their levels of difficulty. Patient and staff dose levels are collected from eight university and central hospitals in Finland. Patient dose levels focus on DAP and air Kerma given by the equipment and skin dose measurements carried out with gafchromic films. KARPO examines dose correlations of multiple factors related to the procedures. The data collected in KARPO will also be used in determining new DRL’s in Finland and two of the hospitals participate in EURALOC project for eye dose dosimetry in cardiological procedures. Results The current data includes PTCA, pacemaker installation, TAVI and electrophysiological procedures from 5 different hospitals in Finland. Current status and preliminary results of the research will be presented. Conclusion The preliminary results indicate clear differences based on level of difficulty.
Julianna C. Simon
University of Washington, Seattle, USA
Title: Investigation into the etiology of the color-Doppler ultrasound twinkling artifact for kidney stone detection
Biography:
Julianna Simon completed her PhD in 2013 from the University of Washington. She is currently working as a National Space Biomedical Research Institute First Award Postdoctoral Fellow at the University of Washington. She has co-authored 12 papers.
Abstract:
The “twinkling artifact,†a rapid color change that highlights hard objects in color- Doppler ultrasound, has the potential to improve kidney stone detection; however, its inconsistent appearance has limited its clinical use. Recently published work supports that crevice micro-bubbles on the kidney stone surface cause twinkling [Lu et al. Ultrasound Med Biol. (2013)]; the work has been challenged because bubbles have not been observed. We used high-magnification, high-speed photography to confirm the presence of bubbles on the kidney stone surface in addition to using a programmable Verasonics ultrasound engine and a custombuilt pressure chamber to analyze the effects of ambient pressure on twinkling. The overpressure threshold to diminish twinkling was found to be dependent on a variety of factors, including the stability of twinkling on the stone, the gas content of the liquid and stone, and the number of cycles in the Doppler pulse. In stable twinkling locations, the artifact was found to disappear at pressures as low as 3 atm (absolute); in other locations, twinkling was only diminished when the pressure exceeded 8 atm. When stones were exposed to hypobaric conditions of 0.2 atm, the twinkling amplitude was found to increase. Upon high-speed photography during color-Doppler ultrasound, a bubble with a maximum diameter of 30 μm was found to oscillate. Results support the crevice bubble hypothesis to describe the origin of the twinkling artifact. [Work supported by the National Space Biomedical Research Institute through NASA NCC 9-58 and NIH grants DK043881 and DK092197].
Javier RodrÃguez
Universidad el Bosque, Colombia.
Title: CLINICAL APPLICATION TO ARRHYTHMIC DYNAMIC OF ENTROPY PROPORTION
Biography:
Dr. Javier Rodriguez is a doctor at the Universidad Nacional de Colombia, founder and director of Insight Group, created in 2001. He has 76 domestic and international original publications, making characterizations, diagnoses and predictions in different areas of medicine, such as fetal and adult cardiology, infectious diseases, immunology, molecular biology, epidemic prediction, cell morphometry and psychology, as well as works in physics. His research is based on the development of predictions from theories and laws of theoretical physics, applicable to each particular case, avoiding the empirical method of trial and error. It has been awarded as one of the 2000 most outstanding researchers century, one of the "Top 100 Health Professionals" and "Man of the Year 2011" by the International Biographical Centre of Cambridge. In 2010 he was awarded in the concourse of Academia Nacional De Medicina-Abbott in the area of Clinical Sciences by a mathematical-physicist diagnostic of cardiac dynamics, with which is possible to make predictions of clinical application. His work has been presented at several international conferences, including the 7th International Meeting of Acute Cardiac Care, 2011, the Innovations in Cardiovascular Interventions - ICI meeting-2012 and the 61st Annual Conference of the Israel Heart Society in 2014, held at the Aviv Israel and the 3rd World Congress on Cancer Science & Therapy - 2013, held in San Francisco. Currently he is a doctor seconded to the Country Clinic and is conducting research with Universidad del Bosque, such as the present presentation.
Abstract:
Introduction: A new diagnostic methodology based on probability and entropy proportions was developed. This methodology has been successful on cardiac dynamic evaluation. Objectives: To apply the diagnostic methodology to the arrhythmic dynamic, evaluating the evolution from normality to acute disease. Method: 75 holter were studied; these records had clinical diagnosis of normality and stable and unstable cardiac arrhythmia. An attractor for each dynamics is generated from the values, obtained each hour, of maximum and minimum frequency and number of beats per minute. From the calculation of the proportions of entropy, the status of each dynamic was mathematically evaluated; showing how close or far is of normal dynamics. The sensibity, specificity and Kappa coefficient were calculated. Results: The normal cases had values into the expected limits. In the same way the cases with stable and unstable cardiac arrhythmia had values for the proportions entropy into disease limits. values of sensibility and specificity of the new method compared with the conventional diagnosis were 100% and the Kappa coefficient value was 1. Conclusions: The results showed the clinical applicability of the diagnostic method, it allowed the quantitative evaluation of each particular dynamics, showing how far is each arrhythmic dynamics of normality. Key words: Entropy, Probability, holter, heart disease, arrhythmia, cardiac dynamics.
Natassa Pippa
National and Kapodistrian University of Athens, Greece
Title: Professor Costas Demetzos: His contribution to bridge the gap between the Biophysics and Pharmaceutical Nanotechnology
Biography:
Natassa Pippa was born in 1987. She has completed her PhD from Faculty of Pharmacy, National and Kapodistrian University of Athens, under the guidance of the expert of Pharmaceutical Nanotechnology, Prof. Costas Demetzos. During her PhD, she participated in the Research Programme “NANOMACRO: Functional Self-assembled Nanostructures from Block Copolymers and Proteins) in Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation. She has published more than 30 peer –review papers and 2 chapters in Books. She has been selected as speaker in National and International Conferences and presented more than 35 posters. She has been awarded in three Congresses for her oral and poster presentations.
Abstract:
Fractal analysis can be an attractive and alternative tool for characterizing the morphology of nanoparticles [1-3]. From the experimental point of view, determined fractal dimension comprehensively illustrates the self-assembly and the morphological complexity of drug nanocarriers. In recent literature, it is well established that the regulatory considerations are of great importance aiming at providing proof, concerning not only the design and preparation protocol of drug delivery systems, but also the final formulation’s physicochemical and morphological characteristics, especially in the pharmaceutical nanotechnology’s area. Additionally, fractal dimension plays a key role in the elucidation of morphological characteristics, while size and/or size distribution of drug nanocarriers did not change by changing the colloidal parameters, like temperature and concentration. In coming years, the above approach could be a useful tool for the development of innovative drug nanocarriers for drug or gene delivery with complete knowledge of their structural and morphological characteristics [4-5]. In conclusion, on the ubiquitous presence of fractals and fractal concepts in Pharmaceutical Sciences, the “pharmaceutical fractalomics†a term which can be correlated with other –omics in pharmaceutics can be considered as an alternative path in the field of novel pharmaceutics. Ref.: [1] Pippa, N., Kaditi, E., Pispas S., Demetzos C., (2013) Soft Matter, 9, 4073-482. [2] Pippa, N., Kaditi, E., Pispas S., Demetzos C., (2013) J. Nanopart. Res., 15,1685.[3] Pippa, N., Merkouraki, M., Pispas S., Demetzos C., (2013) Int. J. Pharm. 450(1-2),1-10. [4] Demetzos, C., Pippa, N., (2014). Int. J. Pharm. 473(1-2):213-8. [5] Pippa N., Dokoumetzidis, A., Demetzos, C., Macheras, P. (2014). Int. J. Pharm. 456(1-2):340-52.